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The study aimed to investigate the morphological and histological feature of spleen between camels and cows. for this research we used seven samples in both animals take off from the slaughter house,The samples were prepare and fixed in neutral buffer formalin10%.The samples processed histological technique by used paraffin section,the sample put in graded series of alcohole and cleared by xylen impregnated and embedded in paraffin wax and finally staining by hematoxylin and eosin staining.The morphological finding appeared the spleen in camels was dark brown in colour and C shaped while redish elongated in cow.Mean length and weight of the spleen was (22.70±0.81 cm) and( 16 ± 0.53 cm) in camele and cow,and weight were recorded of camel turned into (881.39±0.12gr) even as that of cow was (464 ±0.72 gm.), respectively. The width of spleen of camel (16 ± 0.38 cm)while in cow measured as (17± 0.33 cm). Histologically,The spleen was composed of thick capsule measurements as (311±105 mm) divided into an outer layer (121±39 mm) consist of two layer of connective tissue and an inner layer (167±061 mm) composed of mainly of smooth muscle cells. There are two layer under the cortex vascular and avascular trabeculae extend from the capsule, the former containing arteries and nerves but no trabecular veins, the latter being divided structurally into primary and secondary trabeculae The spleen of camel possesses subcapsular and peritrabecular blood sinuses, which are exclusive to this organ. It is noteworthy that the primary and vascular trabeculae are encompassed by these sinuses. Encircling t