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Published manuscripts, although updated, are not providing an exclusive review of the large amount of information that currently exists regarding the immune response of various hosts against different parasites and how are they controlled. In fact, a single chapter would be required to bring together the studies related to the immune response of a single host species (as for example, Bos taurus) against a particular parasite (Babesia bigemina). For this reason, this text aims to summarize the main and most recent aspects of this area of knowledge with the intention of making it useful for the reader. It is also true that, for the designing of an integral control of parasites, it is mandatory to understand other biologic systems, which interact with the immune system as well the strategies used by parasites to evade the effects of the immune system. This chapter is focused on comprehensive strategies of host to control the parasitism.