Quratulain Mujahid 1,2, Ahrar Khan 1,3,*, M. Kashif Saleemi1, M. Farhan Qadir 1,4, Absar Ahmad2, Waseem Ejaz 5, Tahir Zahoor Chohan6, Shahla Mujahid 7, and Jahangir Mujahid 8
1Department of Pathology, University of Agriculture, Faisalabad, Pakistan; 2Para Veterinary Institute Karor Lal Eason, University of Veterinary and Animal Science, Lahore, Layyah Campus, Pakistan; 3Shandong Vocational Animal Science and Veterinary College, Weifang, China; 4College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China; 5University of Veterinary and Animal Sciences, Lahore, Pakistan; 6ALP PARC, Islamabad, Pakistan; 7Health Department Punjab; 8Fatima Memorial Hospital, Lahore, Pakistan
*Corresponding author: ahrar1122@yahoo.com
This study was designed to investigate the allethrin induced toxico-pathological changes in adult male albino rats. A total of 60 adult male albino rats were divided randomly into 4 equal groups. Group A served as control. Groups B, C and D were administered orally Allethrin @ 0.5, 1.0 and 1.5g/kg body for 14 experiment days, respectively. Dullness, erected hairs, alopecia, less response towards feed and water, watery droppings, tremors, convulsions and coma were more prominent signs in treated groups. Feed intake and body weight decreased in all treated groups. Mortality was recorded in group C and D. The total erythrocyte and leukocyte counts, hemoglobin concentration and packed cell volume decreased significantly (P?0.05) in all allethrin treated groups as compared to the control group. Histopathologically, kidneys exhibited condensed nuclei, necrotic tubules and congested renal parenchyma. In liver, vacuolar degeneration in nucleus and cytoplasm was observed. Micro nucleated lymphocytes were also evident in group D treated with the highest dose of allethrin. In conclusion, allethrin induced dose and time dependent toxico-pathological effects in adult male albino rats.