ALLETHRIN INDUCED TOXICOPATHOLOGICAL ALTERATIONS IN ADULT MALE ALBINO RATS
Quratulain Mujahid1,2, Ahrar Khan1,3,*, Muhammad Farhan Qadir1,4, Absar Ahmad2, Waseem Ejaz6, Shahla Mujahid7,
Jahangir Mujahid7, Sobia Khalid8, Tahir Zahoor Chohan9, M. Kashif Saleemi1 and Muhammad Badar5
1Department of Pathology, University of Agriculture, Faisalabad-38040, Pakistan; 2Para Veterinary Institute Karor
Lal Eason (Layyah Campus), University of Veterinary and Animal Science, Lahore, Layyah Campus, Pakistan
3Shandong Vocational Animal Science and Veterinary College, Weifang, China; 4College of Veterinary Medicine,
Shanxi Agricultural University, Jinzhong, China; 5Gomal Centre of Biotechnology and Bio-Chemistry, Gomal
University, Dera Ismail Khan, Pakistan; 6University of Veterinary and Animal Sciences, Lahore, Pakistan
7Health Department, Punjab; 8University of Health Sciences, Lahore; 9ALP PARC Islamabad Pakistan
*Corresponding author: email@example.com
This study was designed to investigate the allethrin induced toxico-pathological changes in adult male albino rats. A total of 60 adult male albino rats were divided randomly into 4 equal groups. Group A was treated as control while group B was given Allethrin @ 0.5g/kg, group C @ 1.0g/kg and group D @1.5g/kg body weight respectively, orally once at day 14 of experiment. Dullness, erected hairs, alopecia, less response towards feed and water, watery droppings, tremors, convulsions and coma were more prominent signs in treated groups. Feed intake and body weight was decreased in all treated groups. Acute mortality was seen in group C and D. The total erythrocyte and leukocyte count, hemoglobin concentration and packed cell volume (P≤0.05) was deviated from normal in all the groups treated with allethrin. Histopathologically, kidneys exhibited condensed nuclei, necrotic tubules and congested renal parenchyma. In liver, vacuolar degeneration in nucleus and cytoplasm was observed. Micro nucleated lymphocytes were also evident in group D treated with highest dose of allethrin. In conclusion, allethrin induced dose and time dependent toxico-pathological effects in adult male albino rats were observed and presented.
Keywords: Allethrin, Albino rats, Toxico-pathology and Genotoxicity.